Invention Grant
- Patent Title: Preparation of thioarabinofuranosyl compounds and use thereof
- Patent Title (中): 硫代呋喃并呋喃糖基化合物的制备及其用途
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Application No.: US12710537Application Date: 2010-02-23
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Publication No.: US08178510B2Publication Date: 2012-05-15
- Inventor: John A. Secrist, III , Kamal N. Tiwari , John A. Montgomery
- Applicant: John A. Secrist, III , Kamal N. Tiwari , John A. Montgomery , William L. Hinds, Jr., legal representative
- Applicant Address: US AL Birmingham
- Assignee: Southern Research Institute
- Current Assignee: Southern Research Institute
- Current Assignee Address: US AL Birmingham
- Agency: Connolly Bove Lodge & Hutz LLP
- Main IPC: A61K31/70
- IPC: A61K31/70 ; A01N43/04

Abstract:
Patients suffering from cancer are treated by being administered a compound represented by the following formula: wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of wherein X is selected from the group consisting of hydrogen, fluorine, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro. The above compounds also inhibit DNA replication in mammalian cells.
Public/Granted literature
- US20100216797A1 PREPARATION OF THIOARABINOFURANOSYL COMPOUNDS AND USE THEREOF Public/Granted day:2010-08-26
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