Invention Grant
- Patent Title: Thiazoles
- Patent Title (中): 噻唑
-
Application No.: US12768779Application Date: 2010-04-28
-
Publication No.: US08178522B2Publication Date: 2012-05-15
- Inventor: Roland Jakob-Roetne , Matthew C. Lucas , Andrew Thomas
- Applicant: Roland Jakob-Roetne , Matthew C. Lucas , Andrew Thomas
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP09159411 20090505
- Main IPC: A61K31/397
- IPC: A61K31/397 ; A61K31/427 ; A61K31/4439 ; A61K31/541 ; A61K31/5377 ; C07D417/06 ; C07D417/14
Abstract:
The present invention is concerned with isoxazole-thiazole derivatives of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
Public/Granted literature
- US20100286116A1 THIAZOLES Public/Granted day:2010-11-11
Information query
