Invention Grant
US08178549B2 Azabicyclo [3. 1. O] hexyl derivatives as modulators of dopamine D3 receptors
失效
氮杂双环[3。 O]己基衍生物作为多巴胺D3受体的调节剂
- Patent Title: Azabicyclo [3. 1. O] hexyl derivatives as modulators of dopamine D3 receptors
- Patent Title (中): 氮杂双环[3。 O]己基衍生物作为多巴胺D3受体的调节剂
-
Application No.: US12680785Application Date: 2008-10-01
-
Publication No.: US08178549B2Publication Date: 2012-05-15
- Inventor: Barbara Bertani , Francesca Cardullo , Paolo Dambruoso , Paola Marzorati , Fabrizio Micheli , Alessandra Pasquarello , Catia Seri , Giovanna Tedesco
- Applicant: Barbara Bertani , Francesca Cardullo , Paolo Dambruoso , Paola Marzorati , Fabrizio Micheli , Alessandra Pasquarello , Catia Seri , Giovanna Tedesco
- Applicant Address: GB Greenford, Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Greenford, Middlesex
- Agent Bonnie L. Deppenbrock
- Priority: GB0719235.4 20071002
- International Application: PCT/EP2008/063166 WO 20081001
- International Announcement: WO2009/043883 WO 20090409
- Main IPC: C07D403/14
- IPC: C07D403/14 ; C07D413/14 ; A61K31/513
![Azabicyclo [3. 1. O] hexyl derivatives as modulators of dopamine D3 receptors](/abs-image/US/2012/05/15/US08178549B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to novel compounds of formula (I) or a salt thereof: wherein R1 is a 5-membered heteroaryl group, optionally fused with a 6-membered hetero or carbocycle; such 5 or 11-membered system, may be optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkoxy and SF5; and n is 1 or 2; their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.
Public/Granted literature
- US20100210672A1 AZABICYCLO [3. 1. O] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS Public/Granted day:2010-08-19
Information query