Invention Grant
US08178550B2 Hydrochloride salts of 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor
有权
8 - [{1-（3,5-双 - （三氟甲基）苯基） - 乙氧基） - 甲基] -8-苯基-1,7-二氮杂 - 螺[4.5]癸-2-酮的盐酸盐和制备方法 因此
![Hydrochloride salts of 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor](/docs/US/2012-05-15/US08178550B2/abs.jpg.600x600.jpg)
- Patent Title: Hydrochloride salts of 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor
- Patent Title (中): 8 - [{1-（3,5-双 - （三氟甲基）苯基） - 乙氧基） - 甲基] -8-苯基-1,7-二氮杂 - 螺[4.5]癸-2-酮的盐酸盐和制备方法 因此
-
Application No.: US11732548Application Date: 2007-04-04
-
Publication No.: US08178550B2Publication Date: 2012-05-15
- Inventor: Mengwei Hu , Sunil Paliwal , Neng-Yang Shih , Frank Bruno Guenter , Ingrid Mergelsberg
- Applicant: Mengwei Hu , Sunil Paliwal , Neng-Yang Shih , Frank Bruno Guenter , Ingrid Mergelsberg
- Applicant Address: US FL Miami
- Assignee: OPKO Health, Inc.
- Current Assignee: OPKO Health, Inc.
- Current Assignee Address: US FL Miami
- Agency: Choate, Hall & Stewart LLP
- Agent Brenda Herschbach Jarrell; Kristen C. Buteau
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A61K31/44 ; C07D215/00 ; C07D217/00 ; C07D219/00 ; C07D221/00
![Hydrochloride salts of 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor](/abs-image/US/2012/05/15/US08178550B2/abs.jpg.150x150.jpg)
Abstract:
Disclosed are hydrochloride and tosylate crystalline salt forms of (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one, represented by Formula I and methods of preparing the same.
Public/Granted literature
Information query
IPC分类:
