Invention Grant
US08178665B2 Process for the production of ezetimibe and intermediates used in this process
有权
用于该方法中使用的依泽替米贝和中间体的生产方法
- Patent Title: Process for the production of ezetimibe and intermediates used in this process
- Patent Title (中): 用于该方法中使用的依泽替米贝和中间体的生产方法
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Application No.: US12097185Application Date: 2006-12-18
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Publication No.: US08178665B2Publication Date: 2012-05-15
- Inventor: József Bódi , János Éles , Katalin Szöke , Krisztina Vukics , Tamás Gáti , Krisztina Temesvári , Dorottya Kiss-Bartos
- Applicant: József Bódi , János Éles , Katalin Szöke , Krisztina Vukics , Tamás Gáti , Krisztina Temesvári , Dorottya Kiss-Bartos
- Applicant Address: HU Budapest
- Assignee: Richter Gedeon Nyrt.
- Current Assignee: Richter Gedeon Nyrt.
- Current Assignee Address: HU Budapest
- Agent Jason D. Voight
- Priority: HU0501164 20051220
- International Application: PCT/HU2006/000116 WO 20061218
- International Announcement: WO2007/072088 WO 20070628
- Main IPC: C07D205/08
- IPC: C07D205/08 ; C07F7/18 ; C07D413/06 ; C07D317/026
Abstract:
A process for the production of 1-(4-3(R)-[3(S)-(4-fluorophenyl)-3-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone (ezetimibe) according to the following reaction scheme: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), (XI) where the substances of the general Formulas II, IV, VI, VIII, IX, X and XI are new, Formula III is a non-isolated intermediate, R1, R2 and R3 are represented by the compounds of Formulas Va-Vd, (Va), (Vb), (Vc), (Vd) and R4 is a silyl, e.g., tert-butyl-dimethyl-silyl, tert-butyl-diphenyl-silyl group.
Public/Granted literature
- US20090216009A1 PROCESS FOR THE PRODUCTION OF EZETIMIBE AND INTERMEDIATES USED IN THIS PROCESS Public/Granted day:2009-08-27
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