Invention Grant
US08178690B2 Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
有权
抑制BCL蛋白与结合配偶体相互作用的化合物和方法
- Patent Title: Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
- Patent Title (中): 抑制BCL蛋白与结合配偶体相互作用的化合物和方法
-
Application No.: US13089530Application Date: 2011-04-19
-
Publication No.: US08178690B2Publication Date: 2012-05-15
- Inventor: Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
- Applicant: Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
- Applicant Address: US MA Cambridge
- Assignee: Infinity Pharmaceuticals, Inc.
- Current Assignee: Infinity Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Foley Hoag LLP
- Main IPC: C07D261/02
- IPC: C07D261/02 ; A61K31/42
Abstract:
The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
Public/Granted literature
- US20110213145A1 Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners Public/Granted day:2011-09-01
Information query
