A method and apparatus for reducing other cell interference in a wireless communication system are provided, in which a symbol generator for generating at least one modulation symbols to be transmitted, a resource mapper for mapping and assigning the modulation symbols into a resource block common to a Base Station (BS) and at least one neighboring Base Station (BS), and a spreader for spreading the mapped modulation symbol with an BS-specific code allocated to the BS, the BS-specific codes of the BS being one of orthogonal and quasi-orthogonal to an BS-specific code allocated to the neighbor BS.