An inter-symbol interference (ISI) pattern-weighted early-late phase detector is provided. I and Q clocks are generated, where the Q clock has a fixed phase delay with respect to the I clock. The I clock frequency is divided by n, creating a reference clock. A serial data stream is sequentially sampled with the I and Q clocks, creating digital I-bit and Q-bit values, respectively. The I-bit values and Q-bit values are segmented into n-bit digital words. In response to analyzing the I-bit and Q-bit values, I clock phase corrections are identified. Also identified are bit sequence patterns associated with each I-bit value. Each I-bit value is weighted in response to the identified bit sequence pattern and the identified I clock phase correction. A phase error signal is generated by averaging the weighted I-bit values for each n-bit digital word, and I clock is modified in phase.