A driving device for a toner cartridge includes a cartridge body and a driving portion disposed on the cartridge body. A transmission mechanism is disposed in the cartridge body. The driving portion includes a driving motor and a controller. The controller receives signal transmitted from a controller unit of a printing apparatus to precisely control the operation of the driving motor. The driving motor is connected with the transmission mechanism. Through the driving action of the driving portion, the transmission load of the printing apparatus can be reduced, and the stability of the printing system can be improved. Moreover, because the driving portion is built in the cartridge body, the gear transmission mechanisms of both of the printing apparatus and the toner cartridge can be simplified, and malfunction can be solved.