Systems and methods for operating of one or more devices before, during, and/or after a power-save mode are provided. The system may include a transmitter device that configures the differential signal lines to low-impedance and a predetermined low-voltage during the power-save mode (such as connecting the differential signal lines to ground). The system may also include a receiver device that senses a wake-up signal, determines the type of wake-up signal, and wakes-up according to the type of wake-up signal.