Invention Grant
- Patent Title: Methods for determining enantiomeric purity with varying chiral analyte concentration
- Patent Title (中): 用不同手性分析物浓度测定对映体纯度的方法
-
Application No.: US12083163Application Date: 2006-10-06
-
Publication No.: US08189188B2Publication Date: 2012-05-29
- Inventor: Kenneth W. Busch , Jemina Rose Ingle , Marianna Busch
- Applicant: Kenneth W. Busch , Jemina Rose Ingle , Marianna Busch
- Applicant Address: US TX Waco
- Assignee: Baylor University
- Current Assignee: Baylor University
- Current Assignee Address: US TX Waco
- Agency: Jackson Walker L.L.P.
- International Application: PCT/US2006/039284 WO 20061006
- International Announcement: WO2007/044602 WO 20070419
- Main IPC: G01J3/00
- IPC: G01J3/00
Abstract:
A new strategy for the quantitative determination of enantiomeric purity that combines guest-host complexation, spectroscopy, and chemometric modeling. Spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-1”) regression. The PLS-1 regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity. In this strategy, the concentration of the chiral compound does not have to be fixed or known.
Public/Granted literature
- US20100045969A1 METHODS FOR DETERMINING ENANTIOMERIC PURITY WITH VARYING CHIRAL ANALYTE CONCENTRATION Public/Granted day:2010-02-25
Information query
