A hole opener having a hybrid reaming section for downhole earth boring operations may include a reamer body having an axis of rotation, an outer periphery, and upper and lower ends, a plurality of rolling cutters coupled to the outer periphery and depending downwardly, the rolling cutters defining a rolling cutter cutting profile having a cutting diameter, a plurality of fixed blade cutters coupled to the outer periphery and defining a fixed blade cutter cutting profile having a cutting diameter, each fixed blade cutter being coupled between adjacent rolling cutters. At least one of the rolling cutters may be asymmetrically coupled about the axis. The cutting diameter of the rolling cutter cutting profile may be larger than the cutting diameter of the fixed blade cutter cutting profile. At least a portion of the rolling cutter cutting profile may be deeper than the fixed blade cutter cutting profile.