The present invention relates to a method of manufacturing an opening leaf upper module intended to be mounted at the periphery of a glass panel of a vehicle, and to an opening leaf upper module of this type particularly comprising a rigid frame and a flexible weather strip.The method of manufacturing an opening leaf upper module (1) according to the invention, comprising a molded frame (3) based on at least one thermoplastic polymer and a molded weather strip (4) secured to the frame and based on at least one elastomer, comprises a step whereby a moving-platen mold or alternatively transfer molding is used to perform multiple-shot injection molding of materials that are intended to form the frame and the strip which are injected in succession, the elastomer being a thermoplastic elastomer compatible with this thermoplastic polymer, so as to obtain the module formed as a single piece.For preference, the strip comprises a continuous wiping lip (8) for wiping the glass panel and an interface lip (9) for interfacing with the bodywork (10) of the vehicle, and the frame has a longitudinal hollow (3b).