Invention Grant
US08192719B2 Methods and kits to diagnose growth hormone deficiency by oral administration of EP 1572 or EP 1573 compounds 有权
通过口服EP 1572或EP 1573化合物诊断生长激素缺乏症的方法和试剂盒

  • Patent Title: Methods and kits to diagnose growth hormone deficiency by oral administration of EP 1572 or EP 1573 compounds
  • Patent Title (中): 通过口服EP 1572或EP 1573化合物诊断生长激素缺乏症的方法和试剂盒
  • Application No.: US12279805
    Application Date: 2007-02-19
  • Publication No.: US08192719B2
    Publication Date: 2012-06-05
  • Inventor: Finn Larsen
  • Applicant: Finn Larsen
  • Applicant Address: DE Frankfurt
  • Assignee: Aeterna Zentaris GmbH
  • Current Assignee: Aeterna Zentaris GmbH
  • Current Assignee Address: DE Frankfurt
  • Agency: LeClairRyan, a Professional Corporation
  • Priority: GB0603295.7 20060218
  • International Application: PCT/GB2007/000566 WO 20070219
  • International Announcement: WO2007/093820 WO 20070823
  • Main IPC: A61K49/10
  • IPC: A61K49/10 G01N33/74 G01N33/50 A61K38/27
Methods and kits to diagnose growth hormone deficiency by oral administration of EP 1572 or EP 1573 compounds
Abstract:
A method of assessing growth hormone deficiency in a human or animal subject, the method comprising administering orally to the subject EP 1572 (Formula I) or EP 1573 (Formula II), obtaining a post-administration sample from the subject, determining the level of growth hormone in the sample and assessing whether the level of growth hormone in the sample is indicative of growth hormone deficiency in the subject. Preferably, the GH level in the sample is measured by immunoassay. Also disclosed is a kit of parts constituting a diagnostic kit comprising: (a) EP 1572 or EP 1573 formulated for oral administration; and (b) means for determining the level of growth hormone in a sample.
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