Invention Grant
US08192753B2 pH-sensitive cationic lipids, and liposomes and nanocapsules containing the same
有权
pH敏感的阳离子脂质和含有它们的脂质体和纳米胶囊
- Patent Title: pH-sensitive cationic lipids, and liposomes and nanocapsules containing the same
- Patent Title (中): pH敏感的阳离子脂质和含有它们的脂质体和纳米胶囊
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Application No.: US10505107Application Date: 2003-02-19
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Publication No.: US08192753B2Publication Date: 2012-06-05
- Inventor: Frank Essler , Steffen Panzner , Gerold Endert
- Applicant: Frank Essler , Steffen Panzner , Gerold Endert
- Applicant Address: US WA Bothell
- Assignee: Marina Biotech, Inc.
- Current Assignee: Marina Biotech, Inc.
- Current Assignee Address: US WA Bothell
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Ivan R. Elrifi
- Priority: DE10207177 20020219
- International Application: PCT/EP03/01661 WO 20030219
- International Announcement: WO03/070220 WO 20030828
- Main IPC: A61K9/127
- IPC: A61K9/127
Abstract:
The invention suggests a pH-sensitive cationic lipid with a pKa value between 3.5 and 8, according to the general formula cation-spacer-Y-spacer-X-lipid, wherein Y and X represent linking groups. Furthermore, liposomes are described, which liposomes include said optionally cationic lipids.
Public/Granted literature
- US20060002991A1 Ph-sensitive cationic lipids, and liposomes and nanocapsules containing the same Public/Granted day:2006-01-05
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