A method for performing a plausibility check of a fuel cell stack anode side pressure sensor to determine whether the pressure sensor is providing an accurate measurement. Prior to system start-up when a cathode side compressor is not providing cathode air to a fuel cell stack, and the cathode side of the stack is at ambient pressure, a pressure measurement from a differential pressure sensor between the anode side and the cathode side of the fuel cell stack is provided. The differential pressure sensor reading is added to a pressure measurement from an ambient pressure sensor, where the sum should be about the same as the pressure measurement from the anode side pressure sensor if the anode side pressure sensor is operating properly.