Invention Grant
US08192955B1 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
失效
编码MPL配体（血小板生成素）的核酸，变体及其片段
- Patent Title: Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
- Patent Title (中): 编码MPL配体（血小板生成素）的核酸，变体及其片段
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Application No.: US08249376Application Date: 1994-05-25
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Publication No.: US08192955B1Publication Date: 2012-06-05
- Inventor: Dan L. Eaton , Frederic J. De Sauvage
- Applicant: Dan L. Eaton , Frederic J. De Sauvage
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Merchant & Gould, P.C.
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/12 ; C12N15/19 ; C07K14/52
Abstract:
Isolated mpl ligand, isolated DNA encoding mpl ligand, and recombinant or synthetic methods of preparing mpl ligand are disclosed. These mpl ligands are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenia.
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