Invention Grant
- Patent Title: Microorganism of the genus Lactobacillus capable of binding to S. mutans and compositions comprising the same
- Patent Title (中): 能够结合变形链球菌的乳杆菌属的微生物和包含其的组合物
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Application No.: US11662347Application Date: 2005-09-09
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Publication No.: US08192978B2Publication Date: 2012-06-05
- Inventor: Bruno Kaesler , Rolf Knöll , Mewes Boettner , Eckhard Budde , Christine Lang , Martin Ryser , Markus Veen
- Applicant: Bruno Kaesler , Rolf Knöll , Mewes Boettner , Eckhard Budde , Christine Lang , Martin Ryser , Markus Veen
- Applicant Address: DE Ludwigshafen
- Assignee: BASF Aktiengesellschaft
- Current Assignee: BASF Aktiengesellschaft
- Current Assignee Address: DE Ludwigshafen
- Agency: Connolly Bove Lodge & Hutz, LLP
- Priority: EP04021591 20040910
- International Application: PCT/EP2005/009724 WO 20050909
- International Announcement: WO2006/027265 WO 20060316
- Main IPC: C12N1/20
- IPC: C12N1/20

Abstract:
The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention.
Public/Granted literature
- US20080193427A1 Means and Methods for Preventing and/or Treating Caries Public/Granted day:2008-08-14
Information query
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