Invention Grant
US08192984B2 Creation of artificial internal ribosome entry site (IRES) elements
失效
创建人造内部核糖体进入位点（IRES）元素
- Patent Title: Creation of artificial internal ribosome entry site (IRES) elements
- Patent Title (中): 创建人造内部核糖体进入位点（IRES）元素
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Application No.: US10489221Application Date: 2002-09-03
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Publication No.: US08192984B2Publication Date: 2012-06-05
- Inventor: Joseph Atabekov , Yurii Dorokhov , Maxim Skulachev , Peter Ivanov , Yuri Gleba
- Applicant: Joseph Atabekov , Yurii Dorokhov , Maxim Skulachev , Peter Ivanov , Yuri Gleba
- Applicant Address: US NJ Princeton
- Assignee: Icon Genetics, Inc.
- Current Assignee: Icon Genetics, Inc.
- Current Assignee Address: US NJ Princeton
- Agency: Lerner, David, Littenberg, Krumholz & Mentlik, LLP
- Priority: DE10143237 20010904
- International Application: PCT/EP02/09843 WO 20020903
- International Announcement: WO03/020927 WO 20030313
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N15/09 ; C12N15/11 ; C12N15/67
Abstract:
A method of producing a nucleic acid sequence having an adenine-rich nucleic acid block of at least 25 nucleotides in length is provided. The nucleic acid sequence that is produced is capable of initiating translation at an internal ribosome entry site (IRES) and the adenine-rich nucleic acid block comprises from 40 to 100 mol-% adenine.
Public/Granted literature
- US20050059004A1 Creation of artificial internal ribosome entry site (ires) elements Public/Granted day:2005-03-17
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