Invention Grant
- Patent Title: Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
- Patent Title (中): 使用分子伴侣来增强哺乳动物细胞中分泌的重组蛋白的产生
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Application No.: US13115417Application Date: 2011-05-25
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Publication No.: US08192985B2Publication Date: 2012-06-05
- Inventor: Sham-Yuen Chan , Hsinyi Yvette Tang , Yiwen Tao , Yongjian Wu , Ruth Kelly
- Applicant: Sham-Yuen Chan , Hsinyi Yvette Tang , Yiwen Tao , Yongjian Wu , Ruth Kelly
- Applicant Address: US CA Berkeley
- Assignee: Bayer Pharmaceuticals Corporation
- Current Assignee: Bayer Pharmaceuticals Corporation
- Current Assignee Address: US CA Berkeley
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/07 ; C12N5/071 ; C12N5/10 ; C12P21/02
Abstract:
The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
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