Invention Grant
US08193158B2 Use of apoptosis-specific eIF-5A siRNA to down regulate expression of proinflammatory cytokines to treat sepsis
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使用细胞凋亡特异性eIF-5A siRNA下调促炎细胞因子的表达以治疗败血症
- Patent Title: Use of apoptosis-specific eIF-5A siRNA to down regulate expression of proinflammatory cytokines to treat sepsis
- Patent Title (中): 使用细胞凋亡特异性eIF-5A siRNA下调促炎细胞因子的表达以治疗败血症
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Application No.: US11725520Application Date: 2007-03-20
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Publication No.: US08193158B2Publication Date: 2012-06-05
- Inventor: John E. Thompson , Charles A. Dinarello
- Applicant: John E. Thompson , Charles A. Dinarello
- Applicant Address: US NJ New Brunswick
- Assignee: Senesco Technologies, Inc.
- Current Assignee: Senesco Technologies, Inc.
- Current Assignee Address: US NJ New Brunswick
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: C12N15/11
- IPC: C12N15/11
Abstract:
The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5-A1, nucleic acids and polypeptides and methods for down regulating pro-inflammatory cytokines in a mammal by administering siRNA against eIF-5A1 to the mammal to treat/prevent sepsis and/or hemorrhagic shock.
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