Invention Grant
- Patent Title: Compositions and methods for siRNA inhibition of ICAM-1
- Patent Title (中): siRNA抑制ICAM-1的组成和方法
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Application No.: US12952046Application Date: 2010-11-22
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Publication No.: US08193163B2Publication Date: 2012-06-05
- Inventor: Samuel J. Reich , Michael J. Tolentino
- Applicant: Samuel J. Reich , Michael J. Tolentino
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Pepper Hamilton LLP
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12Q1/68 ; C12P19/34 ; C01N43/04 ; C12N5/00 ; C12N5/02
Abstract:
RNA interference using small interfering RNAs which are specific for the ICAM-1 gene inhibits expression of this gene. Diseases which involve ICAM-1-mediated cell adhesion, such as inflammatory and autoimmune diseases, diabetic retinopathy and other complications arising from type I diabetes, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
Public/Granted literature
- US20110092571A1 COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ICAM-1 Public/Granted day:2011-04-21
Information query
