Invention Grant
US08193166B2 Epimerized derivatives of K5 polysaccharide with a very high degree of sulfation
有权
具有很高硫酸化程度的K5多糖的差向异构衍生物
- Patent Title: Epimerized derivatives of K5 polysaccharide with a very high degree of sulfation
- Patent Title (中): 具有很高硫酸化程度的K5多糖的差向异构衍生物
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Application No.: US12895894Application Date: 2010-10-01
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Publication No.: US08193166B2Publication Date: 2012-06-05
- Inventor: Pasqua Anna Oreste , Giorgio Zoppetti
- Applicant: Pasqua Anna Oreste , Giorgio Zoppetti
- Applicant Address: IT Milan
- Assignee: Glycores 2000 S.r.l.
- Current Assignee: Glycores 2000 S.r.l.
- Current Assignee Address: IT Milan
- Agency: Nixon & Vanderhye P.C.
- Priority: ITMI2002A1345 20020618; ITMI2002A1346 20020618; ITMI2002A1854 20020827
- Main IPC: C08B37/10
- IPC: C08B37/10 ; C07H19/00 ; C07H21/00 ; C07H21/02 ; A61K31/727 ; C07H5/04 ; C07H5/06
Abstract:
A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives.
Public/Granted literature
- US20110021766A1 EPIMERIZED DERIVATIVES OF K5 POLYSACCHARIDE WITH A VERY HIGH DEGREE OF SULFATION Public/Granted day:2011-01-27
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