Invention Grant
US08193168B2 Use of a TRPM5 inhibitor to regulate insulin and GLP-1 release
有权
使用TRPM5抑制剂调节胰岛素和GLP-1释放
- Patent Title: Use of a TRPM5 inhibitor to regulate insulin and GLP-1 release
- Patent Title (中): 使用TRPM5抑制剂调节胰岛素和GLP-1释放
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Application No.: US12025488Application Date: 2008-02-04
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Publication No.: US08193168B2Publication Date: 2012-06-05
- Inventor: S. Paul Lee , Peihong Zhou , M. N. Tulu Buber , Rok Cerne , Robert Bryant , F. Raymond Salemme , Gillian Morgan
- Applicant: S. Paul Lee , Peihong Zhou , M. N. Tulu Buber , Rok Cerne , Robert Bryant , F. Raymond Salemme , Gillian Morgan
- Applicant Address: US NJ Ewing
- Assignee: Redpoint Bio Corporation
- Current Assignee: Redpoint Bio Corporation
- Current Assignee Address: US NJ Ewing
- Agency: Sterne, Kessler, Goldstein & Fox PLLC
- Main IPC: A61K31/655
- IPC: A61K31/655 ; A61K31/415
Abstract:
The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.
Public/Granted literature
- US20080306030A1 Use of a TRPM5 Inhibitor to Regulate Insulin and GLP-1 Release Public/Granted day:2008-12-11
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