Invention Grant
US08193187B2 1,2,3,4-tetrahydroquinoxaline compound with a phenyl group substituent having a sulfonic acid ester structure or a sulfonic acid amide structure introduced therein and having glucocorticoid receptor-binding activity
失效
具有引入其中具有磺酸酯结构或磺酰胺结构的苯基取代基的1,2,3,4-四氢喹喔啉化合物，并具有糖皮质激素受体结合活性
- Patent Title: 1,2,3,4-tetrahydroquinoxaline compound with a phenyl group substituent having a sulfonic acid ester structure or a sulfonic acid amide structure introduced therein and having glucocorticoid receptor-binding activity
- Patent Title (中): 具有引入其中具有磺酸酯结构或磺酰胺结构的苯基取代基的1,2,3,4-四氢喹喔啉化合物，并具有糖皮质激素受体结合活性
-
Application No.: US12451653Application Date: 2008-05-29
-
Publication No.: US08193187B2Publication Date: 2012-06-05
- Inventor: Mamoru Matsuda , Toshiyuki Mori , Masato Nagatsuka , Sachiko Kobayashi , Masatomo Kato , Miwa Takai
- Applicant: Mamoru Matsuda , Toshiyuki Mori , Masato Nagatsuka , Sachiko Kobayashi , Masatomo Kato , Miwa Takai
- Applicant Address: JP Osaka
- Assignee: Santen Pharmaceutical Co., Ltd.
- Current Assignee: Santen Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Holtz, Holtz, Goodman & Chick, P.C.
- Priority: JP2007-141568 20070529
- International Application: PCT/JP2008/059866 WO 20080529
- International Announcement: WO2008/146871 WO 20081204
- Main IPC: A61K31/495
- IPC: A61K31/495
Abstract:
The compounds represented in general formula (1) or a salt thereof are useful for glucocorticoid receptor modulators. In the formula, R1 represents a lower alkyl group, a lower cycloalkyl group, an aryl group and the like; R2 represents a hydrogen atom, a lower alkyl group and the like; R3 represents a hydrogen atom, a lower alkyl group and the like; R4 and R5 represent a hydrogen atom, a lower alkyl group and the like; R6 represents a hydrogen atom, a lower alkyl group and the like; R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group and the like; W represents an oxygen atom, a sulfur atom, NR8 and the like; R8 represents a hydrogen atom, a lower alkyl group and the like; X represents an oxygen atom or a sulfur atom; Y represents a lower alkylene group and the like; Z represents an oxygen atom, a sulfur atom, NR9, OCO or OSO2; R9 represents a hydrogen atom, a lower alkyl group and the like respectively.
Public/Granted literature
Information query
