Invention Grant
US08193237B2 Indole derivative having IκB kinase β inhibitory activity
失效
具有I&Kgr; B激酶和bgr的吲哚衍生物 抑制活性
- Patent Title: Indole derivative having IκB kinase β inhibitory activity
- Patent Title (中): 具有I&Kgr; B激酶和bgr的吲哚衍生物 抑制活性
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Application No.: US12448826Application Date: 2008-01-15
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Publication No.: US08193237B2Publication Date: 2012-06-05
- Inventor: Hiroshi Enomoto , Kenji Kawashima , Kazuhiro Kudou , Minoru Yamamoto , Masaaki Murai , Takaaki Inaba , Noriko Ishizaka
- Applicant: Hiroshi Enomoto , Kenji Kawashima , Kazuhiro Kudou , Minoru Yamamoto , Masaaki Murai , Takaaki Inaba , Noriko Ishizaka
- Applicant Address: JP Osaka
- Assignee: Santen Pharmaceutical Co., Ltd.
- Current Assignee: Santen Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Holtz, Holtz, Goodman & Chick, P.C.
- Priority: JP2007-005554 20070115
- International Application: PCT/JP2008/050342 WO 20080115
- International Announcement: WO2008/087933 WO 20080724
- Main IPC: A61K31/404
- IPC: A61K31/404 ; C07D209/12

Abstract:
Disclosed is a compound represented by the general formula (1) or a salt thereof. The compound or a salt thereof has an inhibitory activity on IKKβ and is therefore useful as preventive and/or therapeutic agent for a disease associated with IKKβ. In the formula, R1 represents a hydrogen atom, a lower alkyl group, an aryl group, a hydroxy group, or the like; R2 represents a halogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, or the like; and m represents 0, 1, 2, or the like.
Public/Granted literature
- US20100041628A1 NOVEL INDOLE DERIVATIVE HAVING IKAPPAB KINASE BETA INHIBITORY ACTIVITY Public/Granted day:2010-02-18
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