Invention Grant
US08193340B2 Preparation method of porous hyaluronic acid sponge for cell delivery system
有权
多孔透明质酸海绵细胞传递系统的制备方法
- Patent Title: Preparation method of porous hyaluronic acid sponge for cell delivery system
- Patent Title (中): 多孔透明质酸海绵细胞传递系统的制备方法
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Application No.: US12299496Application Date: 2007-05-02
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Publication No.: US08193340B2Publication Date: 2012-06-05
- Inventor: Dae-Duk Kim , Jeong-Yeon Kang , Chung-Wook Chung , In-Soo Yoon , Sun-Young Kim , Byung-Soon Park , Jong-Hyuk Sung
- Applicant: Dae-Duk Kim , Jeong-Yeon Kang , Chung-Wook Chung , In-Soo Yoon , Sun-Young Kim , Byung-Soon Park , Jong-Hyuk Sung
- Applicant Address: KR Seoul KR Seoul
- Assignee: Seoul National University Industry Foundation,Prostemics Co., Ltd.
- Current Assignee: Seoul National University Industry Foundation,Prostemics Co., Ltd.
- Current Assignee Address: KR Seoul KR Seoul
- Agency: Sherr & Vaughn, PLLC
- Priority: KR10-2006-0040652 20060504; KR10-2007-0042611 20070502
- International Application: PCT/KR2007/002162 WO 20070502
- International Announcement: WO2007/129828 WO 20071115
- Main IPC: C08B37/00
- IPC: C08B37/00 ; C07H5/04 ; C07H5/06 ; A61K9/14 ; A61K31/715 ; A01N43/04
Abstract:
Provided is a preparation method of a porous hyaluronic acid sponge comprising the steps of: dissolving hyaluronic acid in an aqueous sodium hydroxide solution; adding an epoxy-based crosslinking agent to the resultant aqueous sodium hydroxide solution in which hyaluronic acid is dissolved and homogenizing the hyaluronic acid solution; hydrogelating the homogenized hyaluronic acid solution; washing the hydrogelated hyaluronic acid hydrogel with ultrapure water; swelling the washed hyaluronic acid hydrogel to attain porosity; and freeze-drying the hyaluronic acid hydrogel to obtain a porous hyaluronic acid sponge.
Public/Granted literature
- US20110268706A1 PREPARATION METHOD OF POROUS HYALURONIC ACID SPONGE FOR CELL DELIVERY SYSTEM Public/Granted day:2011-11-03
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