Invention Grant
US08193363B2 Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits
有权
适合用作成像淀粉样蛋白沉积物的化合物的前体的化合物
- Patent Title: Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits
- Patent Title (中): 适合用作成像淀粉样蛋白沉积物的化合物的前体的化合物
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Application No.: US12544556Application Date: 2009-08-20
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Publication No.: US08193363B2Publication Date: 2012-06-05
- Inventor: Seth Björk , Peter Johnström , Nils Anders Nilsson , Katinka Ruda , Per Magnus Schou , Britt-Marie Swahn , Vern Delisser
- Applicant: Seth Björk , Peter Johnström , Nils Anders Nilsson , Katinka Ruda , Per Magnus Schou , Britt-Marie Swahn , Vern Delisser
- Applicant Address: SE Sodertalje
- Assignee: AstraZeneca AB
- Current Assignee: AstraZeneca AB
- Current Assignee Address: SE Sodertalje
- Agent David Gryte
- Main IPC: C07D405/04
- IPC: C07D405/04
Abstract:
The present invention relates to novel derivatives that are suitable as precursors to compounds that are useful for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. The compounds deriving from these precursors are useful in methods of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease by positron emission tomography (PET) as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents. Furthermore, the present invention also discloses the precursor compounds in crystalline form.
Public/Granted literature
- US20100056796A1 Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits Public/Granted day:2010-03-04
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