Invention Grant
US08193368B2 Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists
有权
四唑取代的芳酰胺如P2X3和P2X2 / 3拮抗剂
- Patent Title: Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists
- Patent Title (中): 四唑取代的芳酰胺如P2X3和P2X2 / 3拮抗剂
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Application No.: US12583325Application Date: 2009-08-18
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Publication No.: US08193368B2Publication Date: 2012-06-05
- Inventor: Michael Patrick Dillon , Ronald Charles Hawley , Li Chen , Lichun Feng , Minmin Yang
- Applicant: Michael Patrick Dillon , Ronald Charles Hawley , Li Chen , Lichun Feng , Minmin Yang
- Applicant Address: US CA Palo Alto
- Assignee: Roche Palo Alto LLC
- Current Assignee: Roche Palo Alto LLC
- Current Assignee Address: US CA Palo Alto
- Agent Robert C. Hall
- Main IPC: C07D257/04
- IPC: C07D257/04
Abstract:
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5 and R6 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
Public/Granted literature
- US20090326220A1 Tetrazole-Substituted Arylamides as P2X3 and P2X2/3 Antagonists Public/Granted day:2009-12-31
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