Efficient heuristic methods are described for approximating the optimal leader strategy for security domains where threats come from unknown adversaries. These problems can be modeled as Bayes-Stackelberg games. An embodiment of the heuristic method can include defining a patrolling or security domain problem as a mixed-integer quadratic program. The mixed-integer quadratic program can be converted to a mixed-integer linear program. For a single follower (e.g., robber or terrorist) scenario, the mixed-integer linear program can be solved, subject to appropriate constraints. For embodiments applicable to multiple follower situations, the relevant mixed-integer quadratic program and related mixed-integer linear program can be decomposed, e.g., by changing the response function for the follower from a pure strategy to a weighted combination over various pure follower strategies where the weights are probabilities of occurrence of each of the follower types.