An improved medical inspection device at least comprises a hand-held portion, a display portion being connected with the hand-held portion and comprising a first printing circuit board, an image display module, an annular protuberance and at least one electrode contact, an inspection module comprising a joint portion, an inspection portion and a third printing circuit board, wherein the joint portion has a second printing circuit board provided at an inner surface thereof, and the inspection portion further comprises a lens, an image sensing unit and a light source, and a fastening ring that is detachably fastened with the annular protuberance of the display portion so as to firmly fasten the joint portion of the inspection module to the display portion.