Described herein are transdermal delivery devices composed of at least one resealable injection port and at least one local anesthetic reservoir. The device effectively delivers anesthetic to the skin of the subject prior to puncturing the skin by syringes, needle sticks, or other instruments intended to be inserted into the skin. In addition, the transdermal delivery device may include a single use patch that does not include a local anesthetic refill port. The devices are used in combination with an electromotive force in order to enhance pain reduction when a subject is injected with a needle. Devices for imparting an electromotive force to a subject are also described herein.