Invention Grant
US08206713B2 Method of treating cancer using antibodies to a non-ligand binding region of NOTCH2
有权
使用NOTCH2非配体结合区域的抗体治疗癌症的方法
- Patent Title: Method of treating cancer using antibodies to a non-ligand binding region of NOTCH2
- Patent Title (中): 使用NOTCH2非配体结合区域的抗体治疗癌症的方法
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Application No.: US13010486Application Date: 2011-01-20
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Publication No.: US08206713B2Publication Date: 2012-06-26
- Inventor: John A. Lewicki , Austin Gurney , Timothy Hoey , Wan-ching Yen , Sanjeev Satyal
- Applicant: John A. Lewicki , Austin Gurney , Timothy Hoey , Wan-ching Yen , Sanjeev Satyal
- Applicant Address: US CA Redwood City
- Assignee: Oncomed Pharmaceuticals, Inc.
- Current Assignee: Oncomed Pharmaceuticals, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; C07K14/705
Abstract:
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.
Public/Granted literature
- US20110195065A1 Compositions and Methods for Diagnosing and Treating Cancer Public/Granted day:2011-08-11
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