Invention Grant
- Patent Title: Fusion proteins comprising CD4 minimal modules and invasin polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutraliziation epitopes
- Patent Title (中): 包含能够结合HIV包膜并暴露神经中和表位的CD4最小模块和侵袭素多肽的融合蛋白
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Application No.: US11597340Application Date: 2005-06-08
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Publication No.: US08206720B2Publication Date: 2012-06-26
- Inventor: Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W. Barnett , Indresh K. Srivastava , Rino Rappuoli
- Applicant: Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W. Barnett , Indresh K. Srivastava , Rino Rappuoli
- Applicant Address: US CA Emeryville
- Assignee: Novartis Vaccines & Diagnostics, Inc
- Current Assignee: Novartis Vaccines & Diagnostics, Inc
- Current Assignee Address: US CA Emeryville
- Agent Regina Bautista; Helen Lee
- International Application: PCT/US2005/022801 WO 20050608
- International Announcement: WO2006/085959 WO 20060817
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/21 ; A61K38/00 ; A61K39/02 ; C07K1/00
Abstract:
Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
Public/Granted literature
- US20100183653A1 Fusion Proteins Comprising CD4 Minimal Modules and Methods of Use Thereof Public/Granted day:2010-07-22
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