Invention Grant
US08206898B2 RNA exit channel: target and method for inhibition of bacterial RNA polymerase
有权
RNA离子通道：抑制细菌RNA聚合酶的靶标和方法
- Patent Title: RNA exit channel: target and method for inhibition of bacterial RNA polymerase
- Patent Title (中): RNA离子通道：抑制细菌RNA聚合酶的靶标和方法
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Application No.: US10527559Application Date: 2004-05-28
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Publication No.: US08206898B2Publication Date: 2012-06-26
- Inventor: Richard H. Ebright
- Applicant: Richard H. Ebright
- Applicant Address: US NJ New Brunswick
- Assignee: Rutgers, The State University of New Jersey
- Current Assignee: Rutgers, The State University of New Jersey
- Current Assignee Address: US NJ New Brunswick
- Agency: Davidson, Davidson & Kappel, LLC
- International Application: PCT/US2004/016826 WO 20040528
- International Announcement: WO2005/001034 WO 20050106
- Main IPC: C12Q1/70
- IPC: C12Q1/70 ; G01N33/53
Abstract:
The invention provides a target and methods for specific binding and inhibition of RNAP from bacterial species. The invention is directed to a method for identifying agents that bind to a bacterial RNAP homologous RNA-exit-channel amino-acid sequence, comprising preparing a reaction solution comprising the agent to be tested and an entity comprising a bacterial RNAP homologous RNA-exit-channel amino-acid sequence, and detecting presence or amount of binding. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.
Public/Granted literature
- US20060127905A1 Rna-exit-channel: target and method for inhibition of bacterial rna polymerase Public/Granted day:2006-06-15
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