Invention Grant
US08206925B2 Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a delta 9 isoform in predicting inflammatory bowel diseases
有权
人IL-23受体（IL-23R）mRNA的剪接变体和δ9同种型在预测炎症性肠病中的应用
- Patent Title: Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a delta 9 isoform in predicting inflammatory bowel diseases
- Patent Title (中): 人IL-23受体（IL-23R）mRNA的剪接变体和δ9同种型在预测炎症性肠病中的应用
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Application No.: US12386146Application Date: 2009-04-14
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Publication No.: US08206925B2Publication Date: 2012-06-26
- Inventor: Grant Gallagher , Raymond Yu , Shih-hsin Kan , Giacomo Mancini
- Applicant: Grant Gallagher , Raymond Yu , Shih-hsin Kan , Giacomo Mancini
- Applicant Address: US NJ Hamilton
- Assignee: Medical Diagnostic Laboratories, LLC
- Current Assignee: Medical Diagnostic Laboratories, LLC
- Current Assignee Address: US NJ Hamilton
- Agent Siu K. Lo, Esq.
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34 ; C07H21/04
Abstract:
There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R.
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