Invention Grant
- Patent Title: Production of glycoproteins with reduced O-glycosylation
- Patent Title (中): 生产具有降低的O-糖基化的糖蛋白
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Application No.: US12084591Application Date: 2006-11-10
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Publication No.: US08206949B2Publication Date: 2012-06-26
- Inventor: Piotr Bobrowicz , W. James Cook , Warren Kett
- Applicant: Piotr Bobrowicz , W. James Cook , Warren Kett
- Applicant Address: US NH Lebanon
- Assignee: GlycoFi, Inc.
- Current Assignee: GlycoFi, Inc.
- Current Assignee Address: US NH Lebanon
- Agent John David Reilly; Immac J. Thampoe
- International Application: PCT/US2006/043535 WO 20061110
- International Announcement: WO2007/061631 WO 20070531
- Main IPC: C12P21/06
- IPC: C12P21/06 ; C12N1/15 ; C12N1/19 ; A01N43/78 ; C07D277/26
Abstract:
A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more α-1,2-mannosidases.
Public/Granted literature
- US20090170159A1 PRODUCTION OF GLYCOPROTEINS WITH REDUCED O-GLYCOSYLATION Public/Granted day:2009-07-02
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