Invention Grant
- Patent Title: Stabilized liquid anti-RSV antibody formulations
- Patent Title (中): 稳定液体抗RSV抗体制剂
-
Application No.: US13184455Application Date: 2011-07-15
-
Publication No.: US08206951B2Publication Date: 2012-06-26
- Inventor: Cynthia N. Oliver , Erica Shane , Benjamin S. Isaacs , Christian B. Allan , Stephen T. Chang
- Applicant: Cynthia N. Oliver , Erica Shane , Benjamin S. Isaacs , Christian B. Allan , Stephen T. Chang
- Applicant Address: US MD Gaithersburg
- Assignee: MedImmune, LLC
- Current Assignee: MedImmune, LLC
- Current Assignee Address: US MD Gaithersburg
- Agency: Jones Day
- Main IPC: C12N5/07
- IPC: C12N5/07 ; C12N5/16 ; C12P21/04

Abstract:
The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention.
Public/Granted literature
- US20120039876A1 STABILIZED LIQUID ANTI-RSV ANTIBODY FORMULATIONS Public/Granted day:2012-02-16
Information query