Invention Grant
- Patent Title: Modified Luciola cruciata luciferase protein
- Patent Title (中): 修饰的Luciola cruciata萤光素酶蛋白
-
Application No.: US12800830Application Date: 2010-05-24
-
Publication No.: US08206961B2Publication Date: 2012-06-26
- Inventor: Daniel J. Coleman , John J. Naleway , Gabriele M. Cook
- Applicant: Daniel J. Coleman , John J. Naleway , Gabriele M. Cook
- Applicant Address: US OR Eugene
- Assignee: Marker Gene Technologies, Inc.
- Current Assignee: Marker Gene Technologies, Inc.
- Current Assignee Address: US OR Eugene
- Agent Timothy L. McCutcheon
- Main IPC: C12N9/02
- IPC: C12N9/02 ; C07K1/00 ; C12P21/06
Abstract:
A codon optimized and stabilized luciferase gene based upon the sequence of the natural luciferase gene isolated from Luciola cruciata (Japanese firefly) and a novel recombinant DNA characterized by incorporating this new gene coding for a novel luciferase into a vector DNA for improved activities in mammalian cells, are disclosed. This new luciferase exhibits long-wavelength light emission, as well as improved thermostability and higher expression levels in mammalian cell systems, compared to native luciferase.
Public/Granted literature
- US20120034634A1 MODIFIED LUCIOLA CRUCIATA LUCIFERASE PROTEIN Public/Granted day:2012-02-09
Information query
