The present invention enables to keep the culture vessel clean with the clean air without touching the open air in which floating bacteria exist, and to culture cells with taking in and out the culture apparatus under the environment with low damages for the cells in constant temperature. The present invention is the culture vessel box which has one or more culture vessels, has the heater, and has the door outside which the good adhesive resin film is stuck, the culture apparatus which has various apparatuses including a heater and culture cells, and has the door outside which the resin film is stuck similarly to the culture vessel box and has its storing chamber. So, it is characterized in that the culture vessel box and the culture apparatus are connected with keeping an interior of the culture vessel box, including a culture vessel, and the interior of the culture apparatus in the clean state and constant temperature by sticking mutual doors of the culture vessel box and culture apparatus at the time of connection to confine the dirty portion which touched on open air by adhesiveness of their resin films, and moving the doors to the door storing chamber integrally.