Invention Grant
- Patent Title: Tricistronic vectors and uses therefor
- Patent Title (中): 三顺反子载体及其用途
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Application No.: US10522535Application Date: 2003-07-30
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Publication No.: US08206977B2Publication Date: 2012-06-26
- Inventor: Josef Prassler , Yvonne Stark
- Applicant: Josef Prassler , Yvonne Stark
- Applicant Address: DE
- Assignee: MorphoSys AG
- Current Assignee: MorphoSys AG
- Current Assignee Address: DE
- International Application: PCT/IB03/03681 WO 20030730
- International Announcement: WO2004/013276 WO 20040212
- Main IPC: C12N15/13
- IPC: C12N15/13 ; C12P21/02
Abstract:
A tricistronic vector (i.e., a vector capable of expressing three exogenous genes, which are not fused together, under the control of one promoter) effectively can encode an immunoglobulin-presenting polypeptide and two immunoglobulin (Ig) polypeptides. The encoded Ig-presenting polypeptide is able to associate with at least one of the Ig polypeptides via co-expressed associating agents. A vector according to the present invention particularly is suited for phage display technology, e.g., when the Ig-presenting polypeptide is a phage coat protein and the Ig polypeptides associate to form a Fab.
Public/Granted literature
- US20060121563A1 Novel tricistronic vectors and uses therefor Public/Granted day:2006-06-08
Information query
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