Invention Grant
- Patent Title: Method for producing red blood cells
- Patent Title (中): 红细胞生成方法
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Application No.: US11597509Application Date: 2005-03-11
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Publication No.: US08206979B2Publication Date: 2012-06-26
- Inventor: Marie-Catherine Giarratana , Luc Douay
- Applicant: Marie-Catherine Giarratana , Luc Douay
- Applicant Address: FR Paris
- Assignee: Universite Pierre et Marie Curie — Paris VI
- Current Assignee: Universite Pierre et Marie Curie — Paris VI
- Current Assignee Address: FR Paris
- Agency: Young & Thompson
- International Application: PCT/IB2005/000626 WO 20050311
- International Announcement: WO2005/118780 WO 20051215
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/10
Abstract:
The invention relates to a method for the expansion and differentiation of haematopoietic stem cells into enucleated erythrocytes, in two steps: a first step in a culture medium, where cell proliferation and erythmid differentiation are induced in the presence of growth factors, and a second step modeling a reconstitution of the microenvironment, substantially without erythropoietin (EPO). Optionally, the method of culture may comprise an intermediate step, with haematopoietic growth factors.
Public/Granted literature
- US20070218552A1 Method for Producing Red Blood Cells Public/Granted day:2007-09-20
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