Invention Grant
US08206989B2 Method of generating a dosing schedule using gamma secretase notch biomarkers
有权
使用γ分泌酶缺口生物标志物产生给药方案的方法
- Patent Title: Method of generating a dosing schedule using gamma secretase notch biomarkers
- Patent Title (中): 使用γ分泌酶缺口生物标志物产生给药方案的方法
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Application No.: US13166103Application Date: 2011-06-22
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Publication No.: US08206989B2Publication Date: 2012-06-26
- Inventor: Rex Denton , Jere E. Meredith
- Applicant: Rex Denton , Jere E. Meredith
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Melissa Miller
- Main IPC: G01N33/483
- IPC: G01N33/483 ; G01N33/50 ; G01N33/53 ; C07K14/435 ; A61K38/00
Abstract:
The present invention relates to the biomarker TFF-3 that measures γ-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity associated with inhibition of Notch processing mediated by γ-secretase. The reagents and methods of the invention can be utilized before, after, or concurrently with, pre-clinical, clinical, and/or post-clinical testing. The reagents and methods of the invention can be used to identify and maintain preferred doses of test compounds and thereby prevent medical complications, such as gastrointestinal cellular damage.
Public/Granted literature
- US20110250625A1 GAMMA SECRETASE NOTCH BIOMARKERS Public/Granted day:2011-10-13
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