Invention Grant
- Patent Title: ITL3 polypeptides and uses thereof
- Patent Title (中): ITL3多肽及其用途
-
Application No.: US11661877Application Date: 2005-09-01
-
Publication No.: US08207110B2Publication Date: 2012-06-26
- Inventor: Nicole Suciu-Foca , Luigi Scotto , Seunghee Kim-Schulze , George Vlad , Raffaello Cortesini
- Applicant: Nicole Suciu-Foca , Luigi Scotto , Seunghee Kim-Schulze , George Vlad , Raffaello Cortesini
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Evans & Molinelli PLLC
- Agent Judith A. Evans
- International Application: PCT/US2005/031380 WO 20050901
- International Announcement: WO2006/033811 WO 20060330
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
This invention provides a first polypeptide comprising all or a portion of the extracellular domain of ILT3, wherein the polypeptide is water-soluble and does not comprise the Fc portion of an immunoglobulin. This invention also provides a second polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) the Fc portion of an immunoglobulin, wherein the Fc portion of the immunoglobulin comprises a function-enhancing mutation, and wherein the polypeptide is water-soluble. This invention further provides a third polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) a transmembrane domain. This invention further provides related nucleic acids, expression vectors, host vector systems, compositions, and articles of manufacture and therapeutic and prophylactic methods using the polypeptides of the invention.
Public/Granted literature
- US20080311073A1 Ilt3 Polypeptides and Uses Thereof Public/Granted day:2008-12-18
Information query
IPC分类:
