Invention Grant
- Patent Title: Oligomeric compounds for the modulation of HIF-1α expression
- Patent Title (中): 低分子化合物用于调节HIF-1α表达
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Application No.: US12913173Application Date: 2010-10-27
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Publication No.: US08207140B2Publication Date: 2012-06-26
- Inventor: Charlotte Albaek Thrue , Anja Molhart Hog , Paul E. G. Kristjansen
- Applicant: Charlotte Albaek Thrue , Anja Molhart Hog , Paul E. G. Kristjansen
- Applicant Address: DK Hersholm US NJ Piscataway
- Assignee: Santaris Pharma A/S,Enzon Pharmaceuticals, Inc.
- Current Assignee: Santaris Pharma A/S,Enzon Pharmaceuticals, Inc.
- Current Assignee Address: DK Hersholm US NJ Piscataway
- Agency: Stoel Rives LLP
- Main IPC: A61K48/00
- IPC: A61K48/00
Abstract:
Oligonucleotides directed against the hypoxia-inducible factor-1α (HIF-1α) gene are provided for modulating the expression of HIF-1α. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1α. Methods of using these compounds for modulation of HIF-1α expression and for the treatment of diseases associated with the hypoxia-inducible factor-1α are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.
Public/Granted literature
- US20110224285A1 OLIGOMERIC COMPOUNDS FOR THE MODULATION OF HIF-1A EXPRESSION Public/Granted day:2011-09-15
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