Invention Grant
US08207143B2 Methods of treating cancer and other conditions or disease states using LFMAU and LDT 有权
使用LFMAU和LDT治疗癌症和其他病症或疾病状态的方法

  • Patent Title: Methods of treating cancer and other conditions or disease states using LFMAU and LDT
  • Patent Title (中): 使用LFMAU和LDT治疗癌症和其他病症或疾病状态的方法
  • Application No.: US13004401
    Application Date: 2011-01-11
  • Publication No.: US08207143B2
    Publication Date: 2012-06-26
  • Inventor: Yung-chi Cheng
  • Applicant: Yung-chi Cheng
  • Applicant Address: US CT New Haven
  • Assignee: Yale University
  • Current Assignee: Yale University
  • Current Assignee Address: US CT New Haven
  • Agent Henry D. Coleman; R. Neil Sudol; William J. Sapone
  • Main IPC: A01N43/04
  • IPC: A01N43/04 A61K31/70
Methods of treating cancer and other conditions or disease states using LFMAU and LDT
Abstract:
The present invention relates to the use of the compound according to formula (I), below for the treatment of tumors, cancer and hyperproliferative diseases, among other conditions or disease states: Where X is H or F; R1 and R2 are independently H, an acyl group, a C1-C20 alkyl or ether group, a phosphate, diphosphate, triphosphate or a phosphodiester group, a (A) or (B) group; Where Nu is a radical of a biologically active compound such as an anticancer, antiviral or antihyperproliferative compound such that an amino group or hydroxyl group from said biologically active agent forms a phosphate, phosphoramidate, carbonate or urethane group with the adjacent moiety; each R8 is independently H, or a C1-C20 alkyl or ether group, preferably a C1-C12 alkyl group; k is 0-12, preferably, 0-2; and pharmaceutically acceptable salts thereof.
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