Invention Grant
US08207160B2 Tetrahydrobenzazepines and their use in he modulation of the dopamine D3 receptor
失效
四氢苯并吖嗪及其在多巴胺D3受体调节中的应用
- Patent Title: Tetrahydrobenzazepines and their use in he modulation of the dopamine D3 receptor
- Patent Title (中): 四氢苯并吖嗪及其在多巴胺D3受体调节中的应用
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Application No.: US10583590Application Date: 2004-12-17
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Publication No.: US08207160B2Publication Date: 2012-06-26
- Inventor: Wilfried Braje , Andreas Haupt , Wilfried Lubisch , Roland Grandel , Karla Drescher , Herve Geneste , Liliane Unger , Daryl R. Sauer
- Applicant: Wilfried Braje , Andreas Haupt , Wilfried Lubisch , Roland Grandel , Karla Drescher , Herve Geneste , Liliane Unger , Daryl R. Sauer
- Applicant Address: DE Wiesbaden
- Assignee: Abbott GmbH & Co. KG
- Current Assignee: Abbott GmbH & Co. KG
- Current Assignee Address: DE Wiesbaden
- Agency: Michael Best & Friedrich LLP
- Agent Lisa V. Mueller
- International Application: PCT/EP2004/014428 WO 20041217
- International Announcement: WO2005/058328 WO 20050630
- Main IPC: A61P25/00
- IPC: A61P25/00 ; A61K31/55 ; C07D223/16 ; C07D409/12

Abstract:
The invention relates to tetrahydrobenzazepines of the general formula I in which the variables Ar, A, B, Y, R1 and R2 have the meanings indicated in claim 1, as well as the N-oxides of these compounds, the physiologically tolerated acid addition salts of these compounds and the physiologically tolerated acid addition salts of the N-oxides. The invention also relates to a pharmaceutical composition that comprises at least one tetrahydrobenzazepine compound of the formula I, the physically tolerated acid addition salt of I, the N-oxide of compound of the formula I and/or the physically tolerated acid addition salts of the N-oxides of I, and further to the use of a compound according to the present invention for treating disorders that respond beneficially to dopamine D3 receptor antagonists or dopamine D3 agonists. The compounds according to the invention are preferably useful for the treatment of disorders of the central nervous system such as schizophrenia and depression and for the treatment of renal function disorders.
Public/Granted literature
- US20090105224A1 Tetrahydrobenzazepines and their use in the modulation of the dopamine d3 receptor Public/Granted day:2009-04-23
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