Invention Grant
- Patent Title: Tricyclic indoles and (4,5-dihydro) indoles
- Patent Title (中): 三环吲哚和(4,5-二氢)吲哚
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Application No.: US12516712Application Date: 2007-11-23
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Publication No.: US08207180B2Publication Date: 2012-06-26
- Inventor: Ermes Vanotti , Marina Caldarelli , Francesco Casuscelli , Barbara Forte , Maria Menichincheri , Alessandra Scolaro , Gabriella Traquandi , Paola Vianello
- Applicant: Ermes Vanotti , Marina Caldarelli , Francesco Casuscelli , Barbara Forte , Maria Menichincheri , Alessandra Scolaro , Gabriella Traquandi , Paola Vianello
- Applicant Address: IT Nerviano (MI)
- Assignee: Nerviano Medical Sciences S.R.L.
- Current Assignee: Nerviano Medical Sciences S.R.L.
- Current Assignee Address: IT Nerviano (MI)
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: EP06124947 20061128
- International Application: PCT/EP2007/062762 WO 20071123
- International Announcement: WO2008/065054 WO 20080605
- Main IPC: A61K31/517
- IPC: A61K31/517 ; A61K31/519 ; A61K31/505 ; A61K31/4353 ; A61K31/416 ; A61K31/4162 ; C07D487/12 ; C07D471/12

Abstract:
The present invention provides tricyclic indoles and (4,5-dihydro) indoles of the formula (I) or a pharmaceutically acceptable salt thereof: wherein the ring A represents a fused pyrazole, pyridine or pyrimidine, means either simple or double carbon-carbon bond and R1, R2 and R3 are as defined in the specification. Further objects of the invention are a process for the preparation of the compounds of the formula (I), pharmaceutical compositions comprising them and methods for treating cell proliferative disorders. As a matter of fact, the compounds of the formula (I) are useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, in particular Cdc7 and AKT kinase activity, like cancer.
Public/Granted literature
- US20100075998A1 TRICYCLIC INDOLES AND (4,5-DIHYDRO) INDOLES Public/Granted day:2010-03-25
Information query
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