Invention Grant
- Patent Title: Compound having affinity for amyloid
- Patent Title (中): 对淀粉样蛋白具有亲和力的化合物
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Application No.: US12312867Application Date: 2007-08-16
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Publication No.: US08207189B2Publication Date: 2012-06-26
- Inventor: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki , Yuki Okumura
- Applicant: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki , Yuki Okumura
- Applicant Address: JP Tokyo
- Assignee: Nihon Medi-Physics Co., Ltd.
- Current Assignee: Nihon Medi-Physics Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fitch, Even, Tabin & Flannery, LLP
- International Application: PCT/JP2007/065955 WO 20070816
- International Announcement: WO2008/065785 WO 20080605
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/44

Abstract:
A compound represented by the following formula or a salt thereof: wherein each of A1, A2, A3 and A4 independently represents a carbon or nitrogen, R1 is a radioactive halogen substituent, R2 is a group selected from the group consisting of hydrogen, a hydroxyl group, a methoxy group, a carboxyl group, an amino group, an N-methylamino group, an N,N-dimethylamino group and a cyano group, and p is an integer of 0 to 2, provided at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4, is effective as an image diagnosis probe targeting amyloid. A diagnostic agent for Alzheimer's disease contains the compound.
Public/Granted literature
- US20100069640A1 NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID Public/Granted day:2010-03-18
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