Invention Grant
- Patent Title: Compounds having a 4-pyridylalkylthio group as a substituent
- Patent Title (中): 具有4-吡啶基烷硫基作为取代基的化合物
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Application No.: US12381290Application Date: 2009-03-10
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Publication No.: US08207194B2Publication Date: 2012-06-26
- Inventor: Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
- Applicant: Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
- Applicant Address: JP Osaka
- Assignee: Santen Pharmaceutical Co., Ltd.
- Current Assignee: Santen Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Holtz, Holtz, Goodman & Chick, P.C.
- Priority: JP2003-062042 20030307; JP2004-011602 20040120
- Main IPC: A61K31/47
- IPC: A61K31/47 ; C07D401/02 ; C07D213/02

Abstract:
A compound having the following formula [I] or a pharmaceutically acceptable salt thereof: wherein A is benzene or an aromatic five-membered heterocycle which optionally is fused with a cycloalkane ring; B is an alkylene; R1 and R2 are hydrogen, hydroxy, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, heterocycle, amino, alkylamino, arylamino or acyl, or R1 and R2 join together to form a heterocycle; X and Y are hydrogen, halogen, hydroxy, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, mercapto, alkylthio, arylthio, carboxyl, an ester of carboxyl, an amide of carboxyl, cyano or nitro; p is 0, 1 or 2; and q is 0 or 1. The compound is useful for treating diseases in which angiogenesis or augmentation of vascular permeability is involved.
Public/Granted literature
- US20090286786A1 Compounds having a 4-pyridylalkylthio group as a substituent Public/Granted day:2009-11-19
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